So we have found an interesting issue with CVAD 1912LTSRCU1 and SEP 14.3. Profiles no likey. There is a telemetry service that even if it is not used, it will lock a certain file or two in the C:\users\%username%\AppData\Local\Microsoft\Windows\WER\ReportArchive and ReportQueue and will freeze the profile and won’t allow you to complete the logoff and profile sync. The files are locked by the system and you can’t delete them. This will clear AFTER you reboot the server, but it will prevent the user from accessing again until the reboot occurs as Citrix still sees it logged on.
This is what you need to fix it. It has a good walkthrough of the requirements to fix it! They are working on a solution and should be later this year for it to be available. Stay safe with thy AV software!